Anti-IL-17 Inhibits PINK1/Parkin Autophagy and M1 Macrophage Polarization in Rheumatic Heart Disease

Ralph, A.P., S. Noonan, V. Wade, and B.J. Currie. 2021. The 2020 Australian guideline for prevention, diagnosis and management of acute rheumatic fever and rheumatic heart disease. The Medical Journal of Australia 214: 220–227.

Article  PubMed  Google Scholar 

Karthikeyan, G., S.J. Connolly, M. Ntsekhe, A. Benz, S. Rangarajan, G. Lewis, Y. Yun, S.K. Sharma, F. Maklady, A.E. Elghamrawy, K. Kazmi, T.T.J. Cabral, H. Dayi, M. Changsheng, B.M. Gitura, A. Avezum, L. Zuhlke, P. Lwabi, A. Haileamlak, O. Ogah, P. Chillo, M. Paniagua, A. ElSayed, A. Dans, L. Gondwe-Chunda, O.J. Molefe-Baikai, J.A. Gonzalez-Hermosillo, J. Hakim, A. Damasceno, E.R. Kamanzi, J. Musuku, K. Davletov, K. Connolly, B.M. Mayosi, and S. Yusuf. 2020. The INVICTUS rheumatic heart disease research program: Rationale, design and baseline characteristics of a randomized trial of rivaroxaban compared to vitamin K antagonists in rheumatic valvular disease and atrial fibrillation. American Heart Journal 225: 69–77.

Article  CAS  PubMed  Google Scholar 

Beaton, A., F.B. Kamalembo, J. Dale, J.H. Kado, G. Karthikeyan, D.S. Kazi, C.T. Longenecker, J. Mwangi, E. Okello, A.L.P. Ribeiro, K.A. Taubert, D.A. Watkins, R. Wyber, M. Zimmerman, and J. Carapetis. 2020. The American Heart Association’s Call to Action for Reducing the Global Burden of Rheumatic Heart Disease: A Policy Statement From the American Heart Association. Circulation 142: e358–e368.

Article  PubMed  Google Scholar 

Yu, J., and W. Wang. 2022. Bioprosthetic vs. Mechanical Mitral Valve Replacement for Rheumatic Heart Disease in Patients Aged 50–70 Years. Frontiers In Cardiovascular Medicine 9: 904958.

Article  PubMed  PubMed Central  Google Scholar 

Remenyi, B., A. ElGuindy, S.C. Smith, M. Yacoub, and D.R. Holmes. 2016. Valvular aspects of rheumatic heart disease. Lancet (London, England) 387: 1335–1346.

Article  PubMed  Google Scholar 

Xian, S., A. Chen, X. Wu, C. Lu, Y. Wu, F. Huang, and Z. Zeng. 2021. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial-mesenchymal transition in the valvular damage due to rheumatic heart disease. Molecular Medicine Reports 23: 1.

Article  Google Scholar 

Ciszewski, W.M., M.E. Wawro, I. Sacewicz-Hofman, and K. Sobierajska. 2021. Cytoskeleton Reorganization in EndMT-The Role in Cancer and Fibrotic Diseases. International Journal of Molecular Sciences 22: 11607.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Locati, M., G. Curtale, and A. Mantovani. 2020. Diversity, Mechanisms, and Significance of Macrophage Plasticity. Annual Review of Pathology 15: 123–147.

Article  CAS  PubMed  Google Scholar 

Kim, A.J., N. Xu, and K.E. Yutzey. 2021. Macrophage lineages in heart valve development and disease. Cardiovascular Research 117: 663–673.

Article  CAS  PubMed  Google Scholar 

Mantovani, A., A. Sica, and M. Locati. 2005. Macrophage polarization comes of age. Immunity 23: 344–346.

Article  CAS  PubMed  Google Scholar 

Akinrinmade, O.A., S. Chetty, A.K. Daramola, M.-U. Islam, T. Thepen, and S. Barth. 2017. CD64: An Attractive Immunotherapeutic Target for M1-type Macrophage Mediated Chronic Inflammatory Diseases. Biomedicines 5: 56.

Article  PubMed  PubMed Central  Google Scholar 

Raddatz, M.A., T. Huffstater, M.R. Bersi, B.I. Reinfeld, M.Z. Madden, S.E. Booton, W.K. Rathmell, J.C. Rathmell, B.R. Lindman, M.S. Madhur, and W.D. Merryman. 2020. Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing. Arteriosclerosis, Thrombosis, and Vascular Biology 40: e153–e165.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, X.-F., Y. Wang, D.-D. Zheng, H.-X. Xu, T. Wang, M. Pan, J.-H. Shi, and J.-H. Zhu. 2016. M1 macrophages promote aortic valve calcification mediated by microRNA-214/TWIST1 pathway in valvular interstitial cells. American Journal of Translational Research 8: 5773–5783.

CAS  PubMed  PubMed Central  Google Scholar 

Shan, M., J. Qin, F. Jin, X. Han, H. Guan, X. Li, J. Zhang, H. Zhang, and Y. Wang. 2017. Autophagy suppresses isoprenaline-induced M2 macrophage polarization via the ROS/ERK and mTOR signaling pathway. Free Radical Biology & Medicine 110: 432–443.

Article  CAS  Google Scholar 

Zhang, M., F. Liu, P. Zhou, Q. Wang, C. Xu, Y. Li, L. Bian, Y. Liu, J. Zhou, F. Wang, Y. Yao, Y. Fang, and D. Li. 2019. The MTOR signaling pathway regulates macrophage differentiation from mouse myeloid progenitors by inhibiting autophagy. Autophagy 15: 1150–1162.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Byles, V., A.J. Covarrubias, I. Ben-Sahra, D.W. Lamming, D.M. Sabatini, B.D. Manning, and T. Horng. 2013. The TSC-mTOR pathway regulates macrophage polarization. Nature Communications 4: 2834.

Article  PubMed  Google Scholar 

Wu, M.-Y., and J.-H. Lu. 2019. Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis. Cells 9: 70.

Article  PubMed  PubMed Central  Google Scholar 

Kim, K.H., and M.-S. Lee. 2014. Autophagy–a key player in cellular and body metabolism. Nature Reviews. Endocrinology 10: 322–337.

Article  CAS  PubMed  Google Scholar 

Sciarretta, S., Y. Maejima, D. Zablocki, and J. Sadoshima. 2018. The Role of Autophagy in the Heart. Annual Review of Physiology 80: 1–26.

Article  CAS  PubMed  Google Scholar 

Fan, Y., J. Shao, S. Wei, C. Song, Y. Li, and S. Jiang. 2021. Self-eating and Heart: The Emerging Roles of Autophagy in Calcific Aortic Valve Disease. Aging and Disease 12: 1287–1303.

Article  PubMed  PubMed Central  Google Scholar 

Yamada, T., S. Satoh, S. Sueyoshi, M. Mitsumata, T. Matsumoto, T. Ueno, K. Uehara, and T. Mizutani. 2009. Ubiquitin-positive foam cells are identified in the aortic and mitral valves with atherosclerotic involvement. Journal of Atherosclerosis and Thrombosis 16: 472–479.

Article  PubMed  Google Scholar 

Liu, X., Q. Zheng, K. Wang, J. Luo, Z. Wang, H. Li, Z. Liu, N. Dong, and J. Shi. 2023. Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF-α/STAT3/autophagy axis. Journal of Cell Communication and Signaling 17 (3): 863–879.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng, L., J. He, C. Liu, F. Zhang, Z. Zhang, H. Chen, Q. Wang, X. Ding, and H. Luo. 2022. Melatonin Attenuates Ropivacaine-Induced Apoptosis by Inhibiting Excessive Mitophagy Through the Parkin/PINK1 Pathway in PC12 and HT22 Cells. Inflammation 45: 725–738.

Article  CAS  PubMed  Google Scholar 

Chang, R., Y. Tang, H. Jia, Z. Dong, S. Gao, Q. Song, H. Dong, Q. Xu, Q. Jiang, J.J. Loor, X. Sun, and C. Xu. 2023. Activation of PINK1-mediated mitophagy protects bovine mammary epithelial cells against lipopolysaccharide-induced mitochondrial and inflammatory damage in vitro. Free Radical Biology & Medicine 194: 172–183.

Article  CAS  Google Scholar 

Yasuda, K., Y. Takeuchi, and K. Hirota. 2019. The pathogenicity of Th17 cells in autoimmune diseases. Seminars In Immunopathology 41: 283–297.

Article  PubMed  Google Scholar 

Kuwabara, T., F. Ishikawa, M. Kondo, and T. Kakiuchi. 2017. The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases. Mediators of Inflammation 2017: 3908061.

Article  PubMed  PubMed Central  Google Scholar 

Bas, H.D., K. Baser, E. Yavuz, H.A. Bolayir, B. Yaman, S. Unlu, A. Cengel, E.U. Bagriacik, and R. Yalcin. 2014. A shift in the balance of regulatory T and T helper 17 cells in rheumatic heart disease. Journal of Investigative Medicine : The Official Publication of the American Federation For Clinical Research 62: 78–83.

Article  CAS  PubMed  Google Scholar 

Chen, A., J. Wen, C. Lu, B. Lin, S. Xian, F. Huang, Y. Wu, and Z. Zeng. 2020. Inhibition of miR-155-5p attenuates the valvular damage induced by rheumatic heart disease. International Journal of Molecular Medicine 45: 429–440.

CAS  PubMed  Google Scholar 

Wen, Y., Z. Zeng, C. Gui, L. Li, and W. Li. 2015. Changes in the expression of Th17 cell-associated cytokines in the development of rheumatic heart disease. Cardiovascular Pathology : The Official Journal of the Society For Cardiovascular Pathology 24: 382–387.

Article  CAS  PubMed  Google Scholar 

Zhang, Q., I. Atsuta, S. Liu, C. Chen, S. Shi, S. Shi, and A.D. Le. 2013. IL-17-mediated M1/M2 macrophage alteration contributes to pathogenesis of bisphosphonate-related osteonecrosis of the jaws. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research 19: 3176–3188.

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