Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome

Kwon T, Lamster IB, Levin L. Current concepts in the management of periodontitis. Int Dent J. 2021;71(6):462–76. https://doi.org/10.1111/idj.12630.

Article  PubMed  PubMed Central  Google Scholar 

Foessl I, Dimai HP, Obermayer-Pietsch B. Long-term and sequential treatment for osteoporosis. Nat Rev Endocrinol. 2023;19(9):520–33. https://doi.org/10.1038/s41574-023-00866-9.

Article  PubMed  Google Scholar 

Yao Q, Wu X, Tao C, et al. Osteoarthritis: pathogenic signaling pathways and therapeutic targets. Signal Transduct Target Ther. 2023;8(1):56. https://doi.org/10.1038/s41392-023-01330-w.

Article  PubMed  PubMed Central  Google Scholar 

Di Matteo A, Bathon JM, Emery P. Rheumatoid arthritis. Lancet. 2023;402(10416):2019–33. https://doi.org/10.1016/s0140-6736(23)01525-8.

Article  PubMed  Google Scholar 

Keller SF, Mandell BF. Management and cure of gouty arthritis. Med Clin N Am. 2021;105(2):297–310. https://doi.org/10.1016/j.mcna.2020.09.013.

Article  PubMed  Google Scholar 

Murakami T, Nakaminami Y, Takahata Y, Hata K, Nishimura R. Activation and function of NLRP3 inflammasome in bone and joint-related diseases. Int J Mol Sci. 2022;23(10):5365. https://doi.org/10.3390/ijms23105365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Quan Y, Lei T, Fan L, Ge X, Hu S. The role of inflammasome NLPR3 in the development and therapy of periodontitis. Int J Med Sci. 2022;19(10):1603–14. https://doi.org/10.7150/ijms.74575.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao Y, Zhang L. Mechanistic and therapeutic insights into the function of NLRP3 inflammasome in sterile arthritis. Front Immunol. 2023;14:1273174. https://doi.org/10.3389/fimmu.2023.1273174.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang N, An J, Yang K, et al. NLRP3 inflammasome: A new target for prevention and control of osteoporosis? Front Endocrinol (Lausanne). 2021;12:752546. https://doi.org/10.3389/fendo.2021.752546.

Article  PubMed  PubMed Central  Google Scholar 

Noonin C, Thongboonkerd V. Exosome-inflammasome crosstalk and their roles in inflammatory responses. Theranostics. 2021;11(9):4436–51. https://doi.org/10.7150/thno.54004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu J, Wu H. Structural mechanisms of nlrp3 inflammasome assembly and activation. Annu Rev Immunol. 2023;41:301–16. https://doi.org/10.1146/annurev-immunol-081022-021207.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang R, Han L, Lin W, et al. Mechanisms of NLRP3 inflammasome in rheumatoid arthritis and osteoarthritis and the effects of traditional Chinese medicine. J Ethnopharmacol. 2024;321: 117432. https://doi.org/10.1016/j.jep.2023.117432.

Article  CAS  PubMed  Google Scholar 

Xu X, Zhang T, Xia X, et al. Pyroptosis in periodontitis: From the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects. Front Cell Infect Microbiol. 2022;12: 953277. https://doi.org/10.3389/fcimb.2022.953277.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leng S, Xu W, Wu L, et al. NLRP3 disturbs Treg/Th17 cell balance to aggravate apical periodontitis. J Dent Res. 2023;102(6):656–66. https://doi.org/10.1177/00220345231151692.

Article  CAS  PubMed  Google Scholar 

Liu J, Jia S, Yang Y, et al. Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF-κB and NLRP3/caspase-1/GSDMD signaling. Biomed Pharmacother. 2023;158: 114118. https://doi.org/10.1016/j.biopha.2022.114118.

Article  CAS  PubMed  Google Scholar 

Tao H, Li W, Zhang W, et al. Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated pyroptosis pathways. Pharmacol Res. 2021;174: 105967. https://doi.org/10.1016/j.phrs.2021.105967.

Article  CAS  PubMed  Google Scholar 

Li W, Wang K, Liu Y, et al. A novel drug combination of mangiferin and cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4/NFκB/NLRP3 activation-induced pyroptosis. Front Immunol. 2022;13: 912933. https://doi.org/10.3389/fimmu.2022.912933.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu H, Chen J, Chen P, et al. Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases. Acta Pharm Sin B. 2023;13(2):678–93. https://doi.org/10.1016/j.apsb.2022.09.014.

Article  CAS  PubMed  Google Scholar 

Li P, Ou Q, Shi S, et al. Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications. Cell Mol Immunol. 2023;20(6):558–69. https://doi.org/10.1038/s41423-023-00998-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang W, Wang T, Xue Y, et al. Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases. Front Immunol. 2023;14:1238789. https://doi.org/10.3389/fimmu.2023.1238789.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zaripova LN, Midgley A, Christmas SE, et al. Mesenchymal stem cells in the pathogenesis and therapy of autoimmune and autoinflammatory diseases. Int J Mol Sci. 2023;24(22):16040. https://doi.org/10.3390/ijms242216040.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han XD, Chen HM, Li C. Effect of human periodontal ligament stem cell-derived extracellular vesicles on macrophage pyroptosis and periodontal inflammatory injury in periodontitis. Cells Tissues Organs. 2022;211(1):57–72. https://doi.org/10.1159/000519569.

Article  CAS  PubMed  Google Scholar 

Liu W, Liu A, Li X, et al. Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223/NLRP3/pyroptosis axis: toward a precision therapy. Bioact Mater. 2023;30:169–83. https://doi.org/10.1016/j.bioactmat.2023.06.012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu L, Zhang F, Cheng G, et al. Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes. Inflamm Res. 2023;72(1):89–105. https://doi.org/10.1007/s00011-022-01655-2.

Article  CAS  PubMed  Google Scholar 

Zhou H, Shen X, Yan C, et al. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage. Stem Cell Res Ther. 2022;13(1):322. https://doi.org/10.1186/s13287-022-03005-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Lu D, Ma W, et al. miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophages. Mol Immunol. 2022;143:68–76. https://doi.org/10.1016/j.molimm.2022.01.002.

Article  CAS  PubMed  Google Scholar 

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