Keywords
Circulating cytokines levels
Circulating growth factors levels
Osteoarthritis
Single-nucleotide polymorphisms
Mendelian randomization
AbbreviationsMR
Mendelian randomization
K/HOA
Knee or hip osteoarthritis
GWAS
Genome-wide association study
MMPs
Matrix metalloproteinases
AOPPs
Advanced oxidation protein products
TNF-α
Tumor necrosis factor
NOXs 4
Nicotinamide adenine dinucleotide phosphate oxidase 4
IVs
Instrumental variables
IBD
Inflammatory bowel disease
SNPs
Single-nucleotide polymorphisms
ArcOGEN
Arthritis Research UK Osteoarthritis Genetics
IVW
Inverse variance weighted
MR-PRESSO
MR pleiotropy residual sum and outlier
FLS
Fibroblast-like synoviocytes
BNGF
Beta nerve growth factor
CTACK
Cutaneous T-cell attracting
GRPa
Growth-regulated protein-α
HGF
Hepatocyte growth factor
IL-12p70
Interleukin-12p70
IL2ra
Interleukin-2 receptor antagonist
IP10
Interferon gamma-induced protein 10
MCP1
Monocyte chemoattractant protein-1
MCSF
Macrophage colony stimulating factor
MIG
Monokine induced by gamma interferon
MIP1b
Macrophage inflammatory protein-1β
PDGFbb
Platelet-derived growth factor BB
RANTES
Regulated on Activation, Normal T Cell Expressed and Secreted
SCGFb
Stem cell growth factor beta
TNFb
Tumor necrosis factor-beta
TRAIL
TNF-related apoptosis inducing ligand
VEGF
Vascular endothelial growth factor
Data availability
The GWAS summary data used in this study are obtained from publicly available database (https://gwas.mrcieu.ac.uk/).
© 2024 The Authors. Published by Elsevier Ltd.
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