We thank all THAOS patients and investigators for their important contributions to this study.

Additional THAOS investigators contributing to this analysis: Violaine Plante-Bordeneuve, CHU Henri Mondor, Créteil, France; Isabel Conceicao, Hospital Santa Maria, Lisboa, Portugal; Eun-Seok Jeon, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Mathew Maurer, Columbia University Medical Center, New York, NY, USA; Jose Gonzalez Costello, Hospital Universitari de Bellvitge, Barcelona, Spain; Olivier Lairez, CHU de Toulouse, Hopital Rangueil, Toulouse, France; Mitsuharu Ueda, Kumamoto University, Kumamoto, Japan; Arnt Kristen, Medical University of Heidelberg, Heidelberg, Germany; Yoshiki Sekijima, Shinshu University School of Medicine, Matsumoto, Japan; Brian Drachman, University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia, PA, USA; David Slosky, Vanderbilt University School of Medicine, Nashville, TN, USA; Anna Hüsing-Kabar, Universitätsklinikum Muenster, Transplant Hepatology, Muenster, Germany; Maria Alejandra Gonzalez Duarte Briseno, Instituto Nacional de Ciencia Medicas y Nutricion Salvador Zubiran, Distrito Federal, Mexico; Miriam Freimer, The Ohio University College of Medicine, Columbus, OH, USA; Marco Luigetti, Fondazione Policlinico Gemelli, Universita Cattolica del Sacro Cuore, Roma, Italy; Daniel Lenihan, Washington University School of Medicine, St. Louis, MO, USA; Michael Polydefkis, Johns Hopkins Hospital, Baltimore, MD, United States; Mazen Hanna, Cleveland Clinic Foundation, Cleveland OH, USA; Hans Nienhuis, University Medical Center Groningen, Groningen, Netherlands; Stephen Gottlieb, University of Maryland, Baltimore, MD, USA; Jose Nativi Nicolau, The University of Utah Health Sciences Center, Salt Lake City, UT, USA; Jocelyn Inamo, Chu De Fort De France, Fort de France, France; Michele Emdin, Fondazione Toscana Gabriele Monasterio Per La Ricerca Medica E Di Sanita Pubblica, Pisa, Italy; Olga Azevedo, Centro Hospitalar Do Alto Ave, Epe, Guimaraes, Portugal; Robert Brunkhorst, University Hospital of RWTH Aachen, Aachen, Germany; Edward Miller, Smilow Cancer Hospital, New Haven, CT, USA; Alberta Warner, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Fabio Adrian Barroso, FLENI, Ciudad Autonoma de Buenos aires, Argentina; Rayomand Press, Karolinska University Hospital, Huddinge, Stockholm, Sweden; Scott Hummel, University of Michigan, Ann Arbor, MI, USA; Francisco Munoz Beamud, Hospital Juan Ramon Jimenez, Huelva, Spain; Anna Mazzeo, AOU Policlinico G. Martino, Messina, Italy; Luca Gentile, AOU Policlinico G. Martino, Messina, Italy; Soon Chai Low, University Malaya Medical Centre, Kuala Lumpur, Malaysia; Sorina Badelita, Institutul De Cardiologie, Bucuresti, Romania; Dianna Quan, UC Denver, Aurora, CO, USA; James Tauras, Montefiore Medical Center, Jack D. Weiler Hospital, Bronx, NY, USA; Sasa Zivkovic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Johan Van Cleemput, Afdeling Klinische Cardiologie, O&N I, Leuven, Belgium; Henning Moelgaard, Aarhus University Hospital, Skejby, Aarhus, Denmark; Josep Maria Campistol Plana, Institut Clinic de Nefrologia i Urologia, ICNU, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain; Roberto Fernandéz Torrón, Hospital Universitario Donostia, Gipuzkoa, San Sebastian, Spain; Nitasha Sarswat, University of Chicago Medical Center, Chicago, IL, USA; Srinivas Murali, Wexford Health and Wellness Pavillion, Pittsburgh, PA, USA; Christopher Mueller, Medical College of Wisconsin, Milwaukee, WI, USA; Nowell Fine, University of Alberta Foothills Medical Centre, Calgary, Canada; Felix Darstein, Johann-Gutenberg-Universität, Mainz, Germany; David Adams, CHU de Bicetre, Cedex, France; Amir Dori, Sheba Medical Center, Ramat Gan, Israel; Laura Obici, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Calogero Lino Cirami, Azienda Ospedaliero-Universitaria di Careggi, Firenze, Italy; Sonoko Misawa, Chiba University Hospital, Chiba-shi, Japan; Sanjiv Shah, Northwestern University, Chicago, IL, USA; Carsten Tschoepe, Charite Campus Rudolf-Virchow-Klinikum, Berlin, Germany; Lucia Galan Davila, Hospital Clinico San Carlos, Madrid, Spain; Jeeyoung Oh, Konkuk University Medical Center, Seoul, Republic of Korea; Yesim Parman, Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Istanbul, Turkey; Tessa Marburger, Oregon Health and Science University, Portland, OR, USA; Jeffrey Ralph, University of California, Department of Neurology, San Francisco, CA, USA.

Juan González-Moreno, Angela Dispenzieri, Martha Grogan, Teresa Coelho, Ivailo Tournev, Márcia Waddington-Cruz, Jonas Wixner, Igor Diemberger, Pablo Garcia-Pavia, Doug Chapman, Pritam Gupta, Oliver Glass and Leslie Amass meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Editorial support was provided by Emily Balevich, PhD, of Engage Scientific Solutions and was funded by Pfizer.